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PURPOSE

Synthesis of Azobenzene: 概要

We synthesize phosphoramidite azobenzene to incorporate DNA into azobenzene.

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Synthesis of Azobenzene: 概要
Synthesis of Azobenzene: 商品

RISULTS AND DISCUSSION

Synthesis of Azobenzene: 概要

SYNTHESIS OF COMPOUND 1

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Synthesis of Azobenzene: 概要

Three spots were observed from the product before column purification by TLC.
The Rf value of Compound 1 in the previous paper was 0.27, and after the column purification, the product having an Rf value of 0.39 was judged as the target product and recovered.

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Synthesis of Azobenzene: 概要

1H-NMR
The figure below shows the results of 1H-NMR of Compound 1.
From the result of 1H-NMR, the value was close to the theoretical value, so it was judged that the amide coupling of the target azobenzene was successful.

NMR1.png
Synthesis of Azobenzene: 概要

SYNTHESIS OF COMPOUND 2

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Synthesis of Azobenzene: 概要

Three spots were observed from the product before column purification by TLC.
The Rf value of Compound 2 in the previous paper was 0.37, and after the column purification, the product having an Rf value of 0.38 was judged as the target product and recovered.

compound2.png
Synthesis of Azobenzene: 概要

1H-NMR

The figure below shows the results of 1H-NMR of Compound 2.

From the result of 1H-NMR, the value was close to the theoretical value. Therefore, it was judged that the target tritylation of azobenzene was successful.

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NMR2.png
Synthesis of Azobenzene: 概要

SYNTHESIS OF COMPOUND 3

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Synthesis of Azobenzene: 概要

Three spots were observed from the product before column purification by TLC.
The Rf value of Compound 3 in the previous paper was 0.63, and after column purification, the product having an Rf value of 0.72 was judged as the target product and recovered.

compound3.png
Synthesis of Azobenzene: 概要
Synthesis of Azobenzene: Service
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